![]() Herxheimer Reaction (Die-off) and NystatinĪt the commencement of my career I was no different to any other clinician of the era and prescribed Nystatin regularly. However when, as often happens, such infections consistently recur I strongly suspect that this is not due to the ineffectiveness of the treatment, but that the external infection actually has an internal cause. The powders, creams and ointments which are available for treating conditions such as Athlete’s Foot, work in exactly the same way as the ingested medications. However although I can appreciated the effectiveness of Nystatin when used as an treatment against internal yeast overgrowth, I am a little more dubious about the ability of this drug to treat external infections. Since ergosterol is actually unique to the cells of fungi, then this is why Nystatin has a specific action and other damage, which can be caused by more broadly acting drugs, is limited. Nystatin then destroys this component which has the overall effect of killing the cell entirely. It does this by attaching itself to a component of the cell wall which is called ergosterol. The way in which it works is to specifically target the cell walls of fungi. But, because its permeability is limited then this allows the medication to be made available in a variety of forms, which include:Īlthough Nystatin is both fungistatic, which means it inhibits the growth of fungi, it is also an extremely effective fungicidal, which means it kills the actual Candida cells. Some clinicians even believe that it cannot be absorbed at all, but the science indicates that this is not in fact correct. However, Nystatin is not without side-effects, despite the fact it is less easily absorbed through mucous membranes including that of the skin and intestinal wall. Everything You Need To Know About Candida Auris.All You Need To Know About Giardia Lamblia.All You Need To Know About Cryptosporidium.Does Candida Cause Sinus Infections, Headaches, and Fatigue?.Drunk Feeling All The Time – Is It Candida?.This is particularly so in the case of Candida, which I have discussed in other articles as being the most opportunistic of yeasts, making the body of an already compromised patient an ideal target. ![]() ![]() Such an invasion of Candida is what is known as being ‘ systemic.’ This means because the body has little or no defense mechanisms, the fungi have literally traveled around the body and set up infections which can become life-threatening. This is very important because for patients with already compromised immune conditions because for them fungal overgrowth can result fatally. It is also routinely used in patients with severely compromised immune conditions, such as those with AIDs or patients undergoing chemotherapy treatment, not only as a treatment, but also as a preventative. The more subtle performance of Nystatin compared to the aggressive ‘zole’ drugs is so significant that many clinicians, even today, believe that it is actually a natural preparation. One of the possible reasons for the continuing popularity of Nystatin compared to that of most modern pharmaceutical treatments is due to its rather more gentle action and the fact that it is less easily absorbed through both the intestinal tract and skin which leaves the user with far fewer side-effects to cope with. ![]()
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